Nucleic Acid Pharmaceutical Solutions

Nucleic Acid Drugs

Nucleic acid drugs are showing great potential as an emerging therapeutic tool. Based on nucleic acids, they can precisely target disease-causing genes and regulate gene expression, thus realizing the treatment of diseases. Compared with traditional drugs, nucleic acid drugs have the advantages of high specificity, high efficiency, flexible design and relatively short research and development cycle - from the treatment of diseases, hereditary diseases to the response to infectious diseases nucleic acid drugs are constantly expanding the field of application, for the attack on a number of difficult diseases to bring a new hope, and is expected to play an important role in the field of medicine in the future.

Target identification and validation

Nucleic acid drug design

Drug Delivery System Development

Synthesis and purification

Quality Control and Inspection

Target identification and validation

In-depth study of disease mechanisms, bioinformatics analysis, gene expression profiling and other means to identify potential nucleic acid drug targets, and then use cell models, animal models, etc. to verify the effectiveness and specificity of the target -NGS primer synthesis.

· Standard gene synthesis

· fixed-point mutation

· siRNA/miRNA/ASO synthesis service

· Exome sequencing

· CRISOPR-sgRNA library construction

· Stabilized cell line construction

Nucleic acid drug design

Suitable nucleic acid drug structures are designed according to the target properties, such as small interfering RI (SENA), antisense oligonucleotide (AS0) micro RA (miEWA) and so on. Meanwhile, the nucleic acid sequence is optimized to improve the stability, targeting and efficacy of the drug.

· Gram-scale recombinant antibody expression service

· siRNA/miRNA/ASO synthesis service

· sgRNA synthesis service

· NGS Safety Evaluation of Nucleic Acid Drugs

· Stabilized cell line construction

Drug Delivery System Development

Efficient delivery systems need to be developed to ensure that nucleic acid drugs can be accurately delivered to target cells or tissues. For this purpose, different delivery vehicles, such as lipid nanoparticles, viral vectors, exosomes, etc., are to be explored.

· DNA/RNA synthesis service

· DNA/RNA retouching service

· siRNA/miRNA/ASO synthesis service

· sgRNA synthesis service

· NGS Safety Evaluation of Nucleic Acid Drugs

Synthesis and purification

Efficient nucleic acid drug synthesis processes have to be established so as to ensure the quality and yield of drugs. At the same time, advanced purification techniques are used to remove impurities and contaminants in order to improve drug purity.

· DNA/RNA synthesis service

· DNA/RNA retouching service

· siRNA/miRNA/ASO synthesis service

Quality Control and Inspection

A strict quality control system needs to be established to comprehensively test the quality of nucleic acid drugs, which includes drug purity, sequence accuracy, stability and biological activity.

· DNA/RNA synthesis service

· DNA/RNA retouching service

· qPCR Probe synthesis

· Eukaryotic/prokaryotic transcriptome sequencing

· NGS Safety Evaluation of Nucleic Acid Drugs

· Gene Editing NGS Safety Evaluation

If you have any questions, please contact us