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Nature Sub-journal (IF=19.4) | GentleGen Supports National University of Singapore in Building the LySE System, Ending the Dilemma of Speed and Accuracy in Directed Evolution!

Company News

2026-07-14

Nature Sub-journal (IF=19.4) | GentleGen Supports National University of Singapore in Building the LySE System, Ending the Dilemma of Speed and Accuracy in Directed Evolution!

A team from the National University of Singapore has developed the LySE directed evolution platform, as reported in Nature Microbiology. By engineering the T7 phage DNA polymerase, the platform enables hypermutation with precise targeting of genes of interest. GentleGen provided the core gene gox0313 with this study, supporting the validation of key platform functions. With just five rounds of evolution, the platform achieved a 25‑fold increase in drug resistance and a 50.9% improvement in PET degradation efficiency, and supports continuous evolution of gene clusters of up to 40 kb.

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Is your siRNA "silent" again? No, silence is useless! A must-read guide for researchers to avoid the pitfalls of oligonucleic acid testing!

Company News

2026-06-26

Is your siRNA "silent" again? No, silence is useless! A must-read guide for researchers to avoid the pitfalls of oligonucleic acid testing!

For small nucleic acid tools such as siRNA and shRNA, this guide covers best practices to avoid common pitfalls across the entire workflow – from sequence design and chemical modification to transfection experiments – including target selection, off‑target control, proper controls, and in vivo delivery strategies. GentleGen's one‑stop service platform deeply integrates core capabilities including target evaluation, sequence design, synthesis and purification, activity screening, and modification conjugation, delivering an "idea‑to‑reality" R&D experience for nucleic acid drug development.

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