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GentleGen × Weixin Computing Strategic Cooperation, AI + Automated Wet and Dry Closed Loop, Jointly Creating a New Paradigm for Drug R&D!
2026-07-24
GentleGen × Weixin Computing Strategic Cooperation, AI + Automated Wet and Dry Closed Loop, Jointly Creating a New Paradigm for Drug R&D!
GentleGen and WeComput have formed a strategic partnership to bridge AI-driven molecular design with automated experimental validation, establishing a closed‑loop iteration of "design → build → test → data". This collaboration shifts drug discovery from random trial‑and‑error to precision engineering, accelerating the translation of life‑science tools from the laboratory to industrial application.
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One-Stop Oligonucleic acid Service: A Full-chain Solution from Target Screening to Cellular Validation!
2026-07-17
One-Stop Oligonucleic acid Service: A Full-chain Solution from Target Screening to Cellular Validation!
Oligonucleotide drug development typically requires screening dozens to hundreds of sequences, followed by multiple rounds of modification and delivery optimization. This process often involves coordination with multiple vendors, making it difficult to trace issues back to their source. GentleGen's one‑stop platform integrates the entire workflow – from target assessment, sequence design, and synthesis/purification to cell‑based validation – enabling a seamless transition from concept to candidate molecule.
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AI Antibodies from Sequence to Protein: Fully Automated, Significantly Reducing R&D Budgets!
2026-07-15
AI Antibodies from Sequence to Protein: Fully Automated, Significantly Reducing R&D Budgets!
AI‑designed antibodies are easy to generate, but high‑throughput validation remains a major bottleneck. GentleGen's fully automated platform enables one‑stop delivery from gene to antibody: IgG monoclonal antibodies at 48.9 USD/clones, nanobodies at 28.9 USD/clones, each with 800 µL of supernatant included – making high‑throughput AI screening a routine laboratory practice.
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ASCO 2026 Insights: The Bispecific Antibody Wave Accelerates Antibody Drug Iteration, Automated Gene Services Lay a Solid Foundation for Innovation!
2026-07-15
ASCO 2026 Insights: The Bispecific Antibody Wave Accelerates Antibody Drug Iteration, Automated Gene Services Lay a Solid Foundation for Innovation!
The bispecific antibody Yiwosi presented updated survival data in lung cancer at ASCO 2026, becoming the first global Phase III trial to achieve positive results on dual primary endpoints. Bispecific antibody development relies heavily on high‑quality gene synthesis, and GentleGen's fully automated platform delivers in just 10 days, supporting innovation at the source.
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Nature Sub-journal (IF=19.4) | GentleGen Supports National University of Singapore in Building the LySE System, Ending the Dilemma of Speed and Accuracy in Directed Evolution!
2026-07-14
Nature Sub-journal (IF=19.4) | GentleGen Supports National University of Singapore in Building the LySE System, Ending the Dilemma of Speed and Accuracy in Directed Evolution!
A team from the National University of Singapore has developed the LySE directed evolution platform, as reported in Nature Microbiology. By engineering the T7 phage DNA polymerase, the platform enables hypermutation with precise targeting of genes of interest. GentleGen provided the core gene gox0313 with this study, supporting the validation of key platform functions. With just five rounds of evolution, the platform achieved a 25‑fold increase in drug resistance and a 50.9% improvement in PET degradation efficiency, and supports continuous evolution of gene clusters of up to 40 kb.
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Is your siRNA "silent" again? No, silence is useless! A must-read guide for researchers to avoid the pitfalls of oligonucleic acid testing!
2026-06-26
Is your siRNA "silent" again? No, silence is useless! A must-read guide for researchers to avoid the pitfalls of oligonucleic acid testing!
For small nucleic acid tools such as siRNA and shRNA, this guide covers best practices to avoid common pitfalls across the entire workflow – from sequence design and chemical modification to transfection experiments – including target selection, off‑target control, proper controls, and in vivo delivery strategies. GentleGen's one‑stop service platform deeply integrates core capabilities including target evaluation, sequence design, synthesis and purification, activity screening, and modification conjugation, delivering an "idea‑to‑reality" R&D experience for nucleic acid drug development.
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Opportunities and Challenges of AAV Gene Therapy, GentleGen: Full-chain technical support for AAV drug development!
2026-06-26
Opportunities and Challenges of AAV Gene Therapy, GentleGen: Full-chain technical support for AAV drug development!
GentleGen provides full‑chain technical support for AAV‑based gene therapy development, spanning from vector construction to regulatory filing for market approval. Its NGSafety® platform is specifically dedicated to quality control and safety assessment of AAV therapeutics, leveraging high‑throughput sequencing to analyze vector genome integrity, integration sites, residual impurities, and replication‑competent AAV (rcAAV) contamination.
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GentlePore nanopore sequencing enables DNA to "pass through tunnels" to read code—GentleGen's third-generation sequencing technology is here!
2026-06-26
GentlePore nanopore sequencing enables DNA to "pass through tunnels" to read code—GentleGen's third-generation sequencing technology is here!
GentleGen's GentlePore nanopore sequencing service enables direct sequencing without fluorescent labeling or PCR amplification, offering the advantages of speed, high accuracy, and low cost.
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In an era of strong regulation, GentleGen' biopharmaceutical safety evaluation collaborates to build a "safety moat" for innovative drugs.
2026-06-26
In an era of strong regulation, GentleGen' biopharmaceutical safety evaluation collaborates to build a "safety moat" for innovative drugs.
GentleGen's NGSafety™ one‑stop safety evaluation platform leverages next‑generation sequencing (NGS) technology to cover mRNA, CRISPR, AAV, and other modalities, delivering a "multi‑assay‑in‑one" capability. Designed to address increasingly stringent regulatory requirements, the platform facilitates IND filings for CGT (cell and gene therapy) products with both the NMPA (China) and the FDA (U.S.).
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From Design to Analysis: GentleGen's CRISPR gRNA Library Screening, One-Step Solution!
2026-06-25
From Design to Analysis: GentleGen's CRISPR gRNA Library Screening, One-Step Solution!
GentleGen's CRISPR gRNA library screening service addresses four critical challenges: low synthesis mutation rate, high sgRNA accuracy, excellent library coverage, and superior uniformity.
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